MovDisordV3, Main, Exploration, bibRecord, 005047

Clozapine use in Parkinson's disease: A retrospective analysis of a large multicentered clinical experience

Identifieur interne : 005047 ( Main/Exploration ); précédent : 005046; suivant : 005048

Clozapine use in Parkinson's disease: A retrospective analysis of a large multicentered clinical experience

Auteurs : Richard M. Trosch [États-Unis] ; Joseph H. Friedman [États-Unis] ; Meg C. Lannon [États-Unis] ; Rajesh Pahwa [États-Unis] ; D. Smith [États-Unis] ; Lauren C. Seeberger [États-Unis] ; Christopher F. O'Brien [États-Unis] ; Peter A. Lewitt [États-Unis] ; William C. Koller [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 1998-05.

RBID : ISTEX:FA580694575C9A074D8D3992108F119B9FC36D73

Descripteurs français

Pascal (Inist)
- Chimiothérapie, Clozapine, Etude multicentrique, Homme, Neuroleptique, Parkinson maladie, Traitement, Trouble psychiatrique.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Aged, Akathisia, Ambulatory Care, Antiparkinson Agents (adverse effects), Antiparkinson Agents (therapeutic use), Antipsychotic Agents (adverse effects), Antipsychotic Agents (therapeutic use), Chemotherapy, Clozapine, Clozapine (adverse effects), Clozapine (therapeutic use), Delirium, Dementia, Amnestic, Cognitive Disorders (drug therapy), Depression, Dose-Response Relationship, Drug, Drug Therapy, Combination, Female, Follow-Up Studies, Human, Humans, Levodopa (adverse effects), Levodopa (therapeutic use), Male, Mental disorder, Middle Aged, Multicenter study, Neuroleptic, Neurologic Examination (drug effects), Neuropsychological Tests, Pain, Parkinson Disease (drug therapy), Parkinson disease, Parkinson's disease, Patient Admission, Psychosis, Retrospective Studies, Treatment, Treatment Outcome.
MESH :
- chemical , adverse effects : Antiparkinson Agents, Antipsychotic Agents, Clozapine, Levodopa.
- chemical , therapeutic use : Antiparkinson Agents, Antipsychotic Agents, Clozapine, Levodopa.
- drug effects : Neurologic Examination.
- drug therapy : Delirium, Dementia, Amnestic, Cognitive Disorders, Parkinson Disease.
- Aged, Ambulatory Care, Dose-Response Relationship, Drug, Drug Therapy, Combination, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neuropsychological Tests, Patient Admission, Retrospective Studies, Treatment Outcome.

Abstract

We conducted a multicentered, retrospective review of clozapine's (CZP) effects on a range of psychiatric, sleep, cognitive, motor, and sensory disorders in Parkinson's disease (PD). Therapeutic outcomes and adverse events were compared with varying prescribing practices at participating sites. The medical records of 172 consecutive PD patients treated with CZP at four movement disorder clinics were reviewed. Low‐dose CZP improved psychiatric symptoms of psychosis, anxiety, depression, hypersexuality, sleep disturbance, and akathisia. Tremor, torticollis, limb dystonia, and pain showed modest rates of improvement. Twenty‐three percent of patients withdrew as a result of adverse events or treatment failure. Inpatient CZP initiation did not improve therapeutic efficacy, or reduce adverse events or the withdrawal rate. Low‐dose CZP in the outpatient setting is generally an effective and well‐tolerated treatment for many of the psychiatric, sleep, motor, and sensory disturbances common to late‐stage PD.

Url:

https://api.istex.fr/document/FA580694575C9A074D8D3992108F119B9FC36D73/fulltext/pdf

DOI: 10.1002/mds.870130302

Affiliations:

États-Unis
Colorado, Kansas, Michigan, Rhode Island

Le document en format XML

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<term>Antiparkinson Agents (therapeutic use)</term>
<term>Antipsychotic Agents (adverse effects)</term>
<term>Antipsychotic Agents (therapeutic use)</term>
<term>Chemotherapy</term>
<term>Clozapine</term>
<term>Clozapine (adverse effects)</term>
<term>Clozapine (therapeutic use)</term>
<term>Delirium, Dementia, Amnestic, Cognitive Disorders (drug therapy)</term>
<term>Depression</term>
<term>Dose-Response Relationship, Drug</term>
<term>Drug Therapy, Combination</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Human</term>
<term>Humans</term>
<term>Levodopa (adverse effects)</term>
<term>Levodopa (therapeutic use)</term>
<term>Male</term>
<term>Mental disorder</term>
<term>Middle Aged</term>
<term>Multicenter study</term>
<term>Neuroleptic</term>
<term>Neurologic Examination (drug effects)</term>
<term>Neuropsychological Tests</term>
<term>Pain</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>Patient Admission</term>
<term>Psychosis</term>
<term>Retrospective Studies</term>
<term>Treatment</term>
<term>Treatment Outcome</term>
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<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Antipsychotic Agents</term>
<term>Clozapine</term>
<term>Levodopa</term>
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<term>Antipsychotic Agents</term>
<term>Clozapine</term>
<term>Levodopa</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Delirium, Dementia, Amnestic, Cognitive Disorders</term>
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<term>Dose-Response Relationship, Drug</term>
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<term>Middle Aged</term>
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<front><div type="abstract" xml:lang="en">We conducted a multicentered, retrospective review of clozapine's (CZP) effects on a range of psychiatric, sleep, cognitive, motor, and sensory disorders in Parkinson's disease (PD). Therapeutic outcomes and adverse events were compared with varying prescribing practices at participating sites. The medical records of 172 consecutive PD patients treated with CZP at four movement disorder clinics were reviewed. Low‐dose CZP improved psychiatric symptoms of psychosis, anxiety, depression, hypersexuality, sleep disturbance, and akathisia. Tremor, torticollis, limb dystonia, and pain showed modest rates of improvement. Twenty‐three percent of patients withdrew as a result of adverse events or treatment failure. Inpatient CZP initiation did not improve therapeutic efficacy, or reduce adverse events or the withdrawal rate. Low‐dose CZP in the outpatient setting is generally an effective and well‐tolerated treatment for many of the psychiatric, sleep, motor, and sensory disturbances common to late‐stage PD.</div>
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<name sortKey="Friedman, Joseph H" sort="Friedman, Joseph H" uniqKey="Friedman J" first="Joseph H." last="Friedman">Joseph H. Friedman</name>
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<name sortKey="Lannon, Meg C" sort="Lannon, Meg C" uniqKey="Lannon M" first="Meg C." last="Lannon">Meg C. Lannon</name>
<name sortKey="Lewitt, Peter A" sort="Lewitt, Peter A" uniqKey="Lewitt P" first="Peter A." last="Lewitt">Peter A. Lewitt</name>
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<name sortKey="Pahwa, Rajesh" sort="Pahwa, Rajesh" uniqKey="Pahwa R" first="Rajesh" last="Pahwa">Rajesh Pahwa</name>
<name sortKey="Seeberger, Lauren C" sort="Seeberger, Lauren C" uniqKey="Seeberger L" first="Lauren C." last="Seeberger">Lauren C. Seeberger</name>
<name sortKey="Smith, D" sort="Smith, D" uniqKey="Smith D" first="D." last="Smith">D. Smith</name>
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Movement Disorders (revue)

Clozapine use in Parkinson's disease: A retrospective analysis of a large multicentered clinical experience

Clozapine use in Parkinson's disease: A retrospective analysis of a large multicentered clinical experience

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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